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Zetasizer Advance

Best-selling DLS/ELS/SLS systemEasy to useAI-based softwareQuick and reliable maintenance and support services from Finland

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Henkilö tietokoneella laitteen Zetasizer kanssa

Zetasizer Advance is the successor to the highly successful and market-leading Nano product family.

Each model in the Zetasizer Advance Range offers particle size, particle charge (zeta potential) and molecular weight analysis.

The product family consists of three models: Lab, Pro and Ultra. Each of the three models is available as a Blue Label or Red Label variant

Choose Blue Label for routine sample investigation such as metallic colloids, metal oxides and pigments
Choose Red Label for more challenging sample types, such as proteins, surfactant solutions and low solid content samples

Zetasizer Advance Ultra

The flagship system offers the advantages of both the Lab and Pro systems. It also offers two unique measurement capabilities: Multi-Angle Dynamic Light Scattering (MADLS®) and particle concentration (Ultra Red Label only).

Zetasizer advance Pro

Versatile system with Non-Invasive Back Scatter (NIBS) technology, among others.

Zetasizer Advance Lab

For determining particle size and zeta potential in a starter-level system. Measurements at 90 degrees.

Product features

Zetasizer Advance Ultra (Red/Blue)

The Zetasizer Ultra is the world’s most capable combined DLS and ELS system, incorporating Non-Invasive Back Scatter (NIBS) and, uniquely, Multi-Angle Dynamic Light Scattering (MADLS) technology for the measurement of particle and molecular size. NIBS provides the versatility and sensitivity to measure over a wide concentration range, while MADLS permits a higher resolution view into your sample’s size distribution.

An extension to MADLS on the Zetasizer Ultra Red Label affords the ability to directly analyse particle concentration. The measurement of particle concentration is suitable for a wide range of materials, requires no or little dilution, and is quick to use – all of which make it ideal as a screening technique. This is a unique capability of the Zetasizer Ultra which can even be applied to samples such as viruses and virus-like particles (VLPs), which were previously very challenging to measure.

Key features of Zetasizer Ultra:

Multi-Angle Dynamic Light Scattering (MADLS) for absolute confidence in particle and molecular size distribution analysis
Dynamic Light Scattering (DLS) measures particle and molecular size, from below 1 nm to 10 µm
Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate
Non-Invasive Back Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements
Simple, per-peak concentration/titre measurements (Red Label only)
Disposable capillary sizing cell provides the ultimate in non-destructive, low volume (down to 3 µL) analysis, with an upper size range that extends to 10 μm
M3-PALS with Constant Current Mode for zeta potential and electrophoretic mobility measurements
ZS Xplorer software suite for simple and flexible method set-up and data analysis
Adaptive Correlation for faster, more repeatable sizing measurements with less sample preparation
Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.
Also includes polarisation filters for DDLS measurements
The optional MPT-3 Autotitrator enables study of the effect of changes in pH
A range of disposable and reusable cells are available

Zetasizer Advance Pro (Blue/Red)

Even novice users of DLS/ELS systems will produce the highest-quality measurements using the Zetasizer Pro.

Dynamic Light Scattering (DLS) measures particle and molecular size, from below 1 nm to 10 µm
Electrophoretic Light Scattering (ELS) measures the zeta potential of particles and molecules, indicating sample stability and/or propensity to aggregate
Non-Invasive Back Scatter (NIBS) optics for versatile, high sensitivity, particle and molecular size measurements
M3-PALS with Constant Current Mode, for zeta potential and electrophoretic mobility measurements
ZS Xplorer software suite, for simple and flexible method set-up and data analysis
Adaptive Correlation for faster, more repeatable sizing measurements with less sample preparation
Deep Learning empowered data quality system for assessment of any size data quality issues, with clear advice on how to improve results
Optical filter wheel with fluorescence filter to allow measurement of fluorescent samples without impairing overall system sensitivity.
Also includes polarisation filters for DDLS measurements
Available in Blue Label and Red Label variants:
Choose Blue Label for routine sample investigation such as metallic colloids, metal oxides and pigments
Choose Red Label for more challenging sample types, such as proteins, surfactant solutions and low solid content samples
On-site upgradeability to Zetasizer Ultra model
The optional MPT-3 Autotitrator enables study of the effect of changes in pH

Zetasizer Advance Lab (Blue/Red)

The Zetasizer Lab is the perfect entry-level system, offering a wide range of features, including:

DLS analysis: particle size measurements from 0.3 nm to 10 μm
Extended size range analysis offers improved accuracy for particle sizes above 1 μm, and indicative results above 10 μm (using ZSU1002 Low Volume Disposable Sizing Cell)
Zeta potential of nanoparticles and colloids using M3-PALS analysis and constant current zeta mode
Molecular weight using Static Light Scattering at 90°
Supports use of Low Volume Disposable Capillary Cell for size measurements in sample volumes as low as 3 μL
Available in Blue Label and Red Label variants:
Choose Blue Label for routine sample investigation such as metallic colloids, metal oxides and pigments
Choose Red Label for more challenging sample types, such as proteins, surfactant solutions and low solid content samples
On-site upgradeability to either Zetasizer Pro or Zetasizer Ultra models

Cells and other accessories

Upgraded auto-titrator MPT-3

Designed to automate your Zeta and/or Size vs. pH titrations, helping you understand how your materials behave as a function of pH. The updated measuring algorithms further improve measurement accuracy.

Zetasizer Advance: new measuring cuvette options

Disposable folded capillary cell DTS1070

The new capillary form improves repeatability. It also helps achieve better thermal power, especially with high-conductivity samples. Although disposable, each cell can be used for hundreds of measurements if required, especially for low conductivity samples. The cell is not suitable for MADLS measuring, but it can be used for other types of sizing.

Uusi kertakäyttöinen kapillaarikyvetti DTS1070

Low-volume disposable sizing cell kit (Ultra and LAB only)

The low volume disposable sizing cell is unique in offering easy-fill, ultra-low volume size measurement in as little as 3 μL. Measure larger particles (up to 10 μm) with greater accuracy without having to adjust the viscosity of the dispersants.

Pienen tilavuuden kyvetti (Ultra ja Lab)

High concentration zeta potential cell kit

Measure the zeta potential of your sample without dilution.

Zetapotentiaalikyvetti -paketti korkean konsentraatioisille näytteille

Universal ‘dip cell’ kit

The dip cell is used for the measurement of zeta potential of samples in aqueous and non-aqueous dispersants, and is designed to be cleaned and reused. It is for batch measurements using standard polystyrene or glass cuvettes.

Universaali ”Dip cell” -paketti

12 mm polystyrene cuvette

Package of 100 disposable cuvettes Compatible with zeta potential measurements using the ‘dip cell’.

12 mm glass cell

For size and molecular weight measurements. Compatible with aqueous and non-aqueous solvents and dispersants.

Specifications

Particle size and molecular size

Measuring principle	Non-Invasive Back Scatter (NIBS) Dynamic Light Scattering Dynamic Light Scattering (90° and 13°) Multi-Angle Dynamic Light Scattering (MADLS)
Measuring angle	173°, 13°, 90°
Measuring range	0.3 nm – 15 μm
Minimum sample volume	3 μL
Concentration range	Minimum sample concentration: Blue Label: 0.2 mg/mL 15 kDa protein Red Label: 0.1 mg/mL 15 kDa protein MADLS: 0.1 mg/mL 15 kDa protein MADLS Particle Concentration Enabled? Blue Label: No Red Label: Yes Maximum sample concentration: 40% w/v

Zeta potential

Measuring principle	Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range	3.8 nm – 100 μm
Min sample volume	20 μL (4)
Concentration range	Red Label: 1 mg/mL (5) to 40% w/v (6) Blue Label: 10 mg/mL (5) to 40% w/v (6)
Sample conductivity range	Max.: 260 mS/cm

Static Light Scattering (molecular weight)

Molecular weight range	980 Da – 20 MDa
Measuring principle	Static Light Scattering with Debye Plot
Accuracy	+/- 10% typical

Particle concentration

Measuring principle

Blue Label: N/A

Red Label: MADLS – particle concentration (Mie)

Concentration range

Blue Label: N/A

Red Label: 1×108 … 1×1012 particles/mL

Calibration type

Blue Label: N/A

Red Label: Single point system calibration only

System

Detector	Avalanche Photodiode
Laser safety	He-Ne (633 nm) Blue label: 4 mW Max Red label: 10 mW Max
Temperature control range	0°C … 120°C
Dimensions (W, D, H)	322 mm x 565 mm x 245 mm
Weight	19 kg
Power	AC 100–240 V, 50–60 Hz, 4.0 A
Power consumption	Max. 100 W, typically 45 W
Ambient conditions	+10°C … +35°C, 35 …80% RH (non-condensing)
Interface	USB 2.0 or newer

Zetasizer Advance Pro

Particle size and molecular size

Measuring principle	Non-Invasive Back Scatter (NIBS) Dynamic Light Scattering Dynamic Light Scattering (90° and 13°) )
Measuring angle	173°, 13°
Measuring range	0.3 nm – 10 μm
Minimum sample volume	12 μL
Concentration range	Minimum sample concentration: Blue Label: 0.2 mg/mL 15 kDa protein Red Label: 0.1 mg/mL 15 kDa protein MADLS: 0.1 mg/mL 15 kDa protein Maximum sample concentration: 40% w/v

Zeta potential

Measuring principle	Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range	3.8 nm – 100 μm
Minimum sample volume	20 μL (4)
Concentration range	Red Label: 1 mg/mL … o 40% w/v Blue Label: 10 mg/mL … 40% w/v
Sample conductivity range	Max.: 260 mS/cm

Static Light Scattering (molecular weight)

Molecular weight range	980 Da – 20 MDa
Measuring principle	Static Light Scattering with Debye Plot
Accuracy	+/- 10% typical

System

Detector	Avalanche Photodiode
Laser safety	He-Ne (633 nm) Blue label: 4 mW Max Red label: 10 mW Max
Temperature control range	0°C … 120°C
Dimensions (W, D, H)	322 mm x 565 mm x 245 mm
Weight	19 kg
Power	AC 100–240 V, 50–60 Hz, 4.0 A
Power consumption	Max. 100 W, typically 45 W
Ambient conditions	+10°C … +35°C, 35 … 80% relative humidity
Interface	USB 2.0 or newer

Zetasizer Advance Lab

Particle size and molecular size

Measuring principle	Classic 90-degree DLS
Measuring angle	90°
Measuring range	0.3 nm – 15 μm
Minimum sample volume	3 μL
Concentration range	Minimum sample concentration: Blue Label: 1 mg/mL 15 kDa protein Red Label: 0.3 mg/mL 15 kDa protein Maximum sample concentration: 40% w/v

Zeta potential

Measuring principle	Mixed-Mode Measurement phase analysis light scattering (M3-PALS)
Size range	3.8 nm – 100 μm
Minimum sample volume	20 μL (4)
Concentration range	Red Label: 1 mg/mL … 40% wt% Blue Label: 10 mg/mL … 40 wt%
Sample conductivity range	Max.: 260 mS/cm

Static Light Scattering (molecular weight)

Molecular weight range	980 Da – 20 MDa
Measuring principle	Static Light Scattering with Debye Plot
Accuracy	+/- 10% typical

System

Detector	Avalanche Photodiode
Laser safety	He-Ne (633 nm) Blue label: 4 mW Max Red label: 10 mW Max
Temperature control range	0°C … 120°C
Dimensions (W, D, H)	322 mm x 565 mm x 245 mm
Weight	19 kg
Power	AC 100–240 V, 50–60 Hz, 4.0 A
Power consumption	Max. 100 W, typically 45 W
Ambient conditions	+10°C … +35°C, 35 …80% RH (non-condensing)
Interface	USB 2.0 or newer